Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase

Jinho Lee; Jonghyun Kim; Jong Sung Koh; Hyun-Ho Chung; Kyoung-Hee Kim

doi:10.1016/j.bmcl.2005.12.074

Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase

Bioorg Med Chem Lett. 2006 Apr 1;16(7):1954-6. doi: 10.1016/j.bmcl.2005.12.074. Epub 2006 Jan 25.

Authors

Jinho Lee¹, Jonghyun Kim, Jong Sung Koh, Hyun-Ho Chung, Kyoung-Hee Kim

Affiliation

¹ Department of Chemistry, Keimyung University, 1000 Sindang-Dong, Dalseo-Gu, Daegu 704-701, Republic of Korea. jinho@kmu.ac.kr

PMID: 16442288
DOI: 10.1016/j.bmcl.2005.12.074

Abstract

1,3,5,5-Tetrasubstituted 2,4-imidazolinedione (hydantoin) derivatives were evaluated as Ftase inhibitors. Potent Ftase inhibitors without thiol or peptide were obtained in three steps.

MeSH terms

Crystallography, X-Ray
Enzyme Inhibitors / pharmacology*
Farnesyltranstransferase / antagonists & inhibitors*
Hydantoins / pharmacology*
Oncogene Protein p21(ras) / antagonists & inhibitors*

Substances

Enzyme Inhibitors
Hydantoins
Farnesyltranstransferase
Oncogene Protein p21(ras)